16S rRNK (adenin1408-N1)-metiltransferaza
(преусмерено са S-adenozil-L-metionin:16S rRNK (adenin1408-N1)-metiltransferaza)
16S rRNK (adenin1408-N1 (EC 2.1.1.180, metilaza kanamicin-apramicinske otpornosti, 16S rRNK:m1A1408 metiltransferaza, KamB, NpmA, 16S rRNK m1A1408 metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:16S rRNK (adenin1408-N1)-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 16S rRNK (adenin1408-N1)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.180 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + adenin1408 u 16S rRNK S-adenozil-L-homocistein + N1-metiladenin1408 u 16S rRNK
Ovaj enzim pruža otpornost na panaminoglikozid ometanjem vezivanja aminoglikozida za A mesto 16S rRNK, tako što N1-metiliše u poziciji adenin1408.
Reference уреди
- ^ Beauclerk, A.A. & Cundliffe, E. (1987). „Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides”. J. Mol. Biol. 193: 661—671. PMID 2441068.
- ^ Koscinski, L., Feder, M. and Bujnicki, J.M. (2007). „Identification of a missing sequence and functionally important residues of 16S rRNA:m1A1408 methyltransferase KamB that causes bacterial resistance to aminoglycoside antibiotics”. Cell Cycle. 6: 1268—1271. PMID 17495534.
- ^ Holmes, D.J., Drocourt, D., Tiraby, G. and Cundliffe, E. (1991). „Cloning of an aminoglycoside-resistance-encoding gene, kamC, from Saccharopolyspora hirsuta: comparison with kamB from Streptomyces tenebrarius”. Gene. 102: 19—26. PMID 1840536.
- ^ Wachino, J., Shibayama, K., Kurokawa, H., Kimura, K., Yamane, K., Suzuki, S., Shibata, N., Ike, Y. and Arakawa, Y. (2007). „Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides”. Antimicrob. Agents Chemother. 51: 4401—4409. PMID 17875999.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- 16S+rRNA+(adenine1408-N1)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
