23S rRNK (adenozin1067-2'-O)-metiltransferaza
(преусмерено са S-adenozil-L-metionin:23S rRNK (adenozin1067-2'-O)-metiltransferaza)
23S rRNK (adenozin1067-2'-O)-metiltransferaza (EC 2.1.1.230, 23S rRNK A1067 2'-metiltransferaza, metilaza tiostreptonske otpornosti, metiltransferaza nosiheptidne otrpornosti) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (adenozin1067-2'-O)-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 23S rRNK (adenozin1067-2'-O)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.230 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + adenozin1067 u 23S rRNK S-adenozil-L-homocistein + 2'-O-metiladenozin1067 u 23S rRNK
Ova metilaza je odgovorna za autoimunost Streptomyces azureus koji formira tiostrepton.
Reference уреди
- ^ Bechthold, A. & Floss, H.G. (1994). „Overexpression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2′-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA”. Eur. J. Biochem. 224: 431—437. PMID 7925357.
- ^ Thompson, J., Schmidt, F. and Cundliffe, E. (1982). „Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton”. J. Biol. Chem. 257: 7915—7917. PMID 6806287.
- ^ Thompson, J. & Cundliffe, E. (1981). „Purification and properties of an RNA methylase produced by Streptomyces azureus and involved in resistance to thiostrepton”. J. Gen. Microbiol. 124: 291—297.
- ^ Yang, H., Wang, Z., Shen, Y., Wang, P., Jia, X., Zhao, L., Zhou, P., Gong, R., Li, Z., Yang, Y., Chen, D., Murchie, A.I. and Xu, Y. (2010). „Crystal structure of the nosiheptide-resistance methyltransferase of Streptomyces actuosus”. Biochemistry. 49: 6440—6450. PMID 20550164.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- 23S+rRNA+(adenosine1067-2'-O)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
