TRNKIle-lizidinska sintaza (EC 6.3.4.19, TilS, mesJ (gen), yacA (gen), izoleucin-specifični transfer ribonukleat lizidinska sintetaza, tRNKIle-lizidinska sintetaza) je enzim sa sistematskim imenom L-lizin:(tRNKIle2)-citidin34 ligaza (formira AMP).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

TRNKIle-lizidinska sintaza
Identifikatori
EC broj6.3.4.19
CAS broj635304-92-6
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
[tRNKIle2]-citidin34 + L-lizin + ATP [tRNKIle2]-lizidin34 + AMP + difosfat + H2O

Bakterijski enzim modifikuje nestabilnu bazu CAU antikodona u tRNKIle molekulu.

Reference уреди

  1. ^ Ikeuchi, Y., Soma, A., Ote, T., Kato, J., Sekine, Y. and Suzuki, T. (2005). „molecular mechanism of lysidine synthesis that determines tRNA identity and codon recognition”. Mol. Cell. 19: 235—246. PMID 16039592. 
  2. ^ Salowe, S.P., Wiltsie, J., Hawkins, J.C. and Sonatore, L.M. (2009). „The catalytic flexibility of tRNAIle-lysidine synthetase can generate alternative tRNA substrates for isoleucyl-tRNA synthetase”. J. Biol. Chem. 284: 9656—9662. PMID 19233850. 
  3. ^ Nakanishi, K., Fukai, S., Ikeuchi, Y., Soma, A., Sekine, Y., Suzuki, T. and Nureki, O. (2005). „Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain”. Proc. Natl. Acad. Sci. USA. 102: 7487—7492. PMID 15894617. 
  4. ^ Soma, A., Ikeuchi, Y., Kanemasa, S., Kobayashi, K., Ogasawara, N., Ote, T., Kato, J., Watanabe, K., Sekine, Y. and Suzuki, T. (2003). „An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA”. Mol. Cell. 12: 689—698. PMID 14527414. 
  5. ^ Nakanishi, K., Bonnefond, L., Kimura, S., Suzuki, T., Ishitani, R. and Nureki, O. (2009). „Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase”. Nature. 461: 1144—1148. PMID 19847269. 

Literatura уреди

Spoljašnje veze уреди