Triprolidin

Triprolidin
Klinički podaci
Prodajno ime	Actidil, Myidyl, Triprolidine HCL, Triprolidine Hydrochloride
Drugs.com	Monografija
Farmakokinetički podaci
Poluvreme eliminacije	4 - 6 h
Identifikatori
CAS broj	486-12-4
ATC kod	R06AX07 (WHO)
PubChem	CID 5282443
IUPHAR/BPS	1228
DrugBank	DB00427
ChemSpider	4445597
ChEMBL	CHEMBL855
Hemijski podaci
Formula	C19H22N2
Molarna masa	278,391
	SMILES CC1=CC=C(C=C1)C(=C/CN1CCCC1)\C1=CC=CC=N1; ;
	InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+ ; Key:CBEQULMOCCWAQT-WOJGMQOQSA-N ;
Fizički podaci
Tačka topljenja	60 °C (140 °F)

Triprolidin je organsko jedinjenje, koje sadrži 19 atoma ugljenika i ima molekulsku masu od 278,391 Da.^[1]^[2]^[3]^[4]^[5]^[6]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	2
Broj donora vodonika	0
Broj rotacionih veza	4
Particioni koeficijent^[7] (ALogP)	4,1
Rastvorljivost^[8] (logS, log(mol/L))	-5,2
Polarna površina^[9] (PSA, Å²)	16,1

Reference

^ Mann, K. V.; Crowe, J. P.; Tietze, K. J. (1989). „Nonsedating histamine H1-receptor antagonists”. Clinical Pharmacy. 8 (5): 331—344. PMID 2568212.
^ Simons, F. E. (1994). „H1-receptor antagonists. Comparative tolerability and safety”. Drug Safety. 10 (5): 350—380. PMID 7913608. doi:10.2165/00002018-199410050-00002.
^ Paton, D. M.; Webster, D. R. (1985). „Clinical pharmacokinetics of H1-receptor antagonists (The antihistamines)”. Clinical Pharmacokinetics. 10 (6): 477—497. PMID 2866055. doi:10.2165/00003088-198510060-00002.
^ Telekes, A.; Holland, R. L.; Withington, D. A.; Peck, A. W. (1987). „Effects of triprolidine and dipipanone in the cold induced pain test, and the central nervous system of healthy volunteers”. Br J Clin Pharmacol. 24 (1): 43—50. PMC 1386278  . PMID 3620284. doi:10.1111/j.1365-2125.1987.tb03134.x.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709  . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889  . PMID 18048412. doi:10.1093/nar/gkm958.
^ . doi:10.1021/jp980230o. Недостаје или је празан параметар |title= (помоћ)
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Triprolidine

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Mann, K. V.; Crowe, J. P.; Tietze, K. J. (1989). „Nonsedating histamine H1-receptor antagonists”. Clinical Pharmacy. 8 (5): 331—344. PMID 2568212.

[2] Simons, F. E. (1994). „H1-receptor antagonists. Comparative tolerability and safety”. Drug Safety. 10 (5): 350—380. PMID 7913608. doi:10.2165/00002018-199410050-00002.

[3] Paton, D. M.; Webster, D. R. (1985). „Clinical pharmacokinetics of H1-receptor antagonists (The antihistamines)”. Clinical Pharmacokinetics. 10 (6): 477—497. PMID 2866055. doi:10.2165/00003088-198510060-00002.

[4] Telekes, A.; Holland, R. L.; Withington, D. A.; Peck, A. W. (1987). „Effects of triprolidine and dipipanone in the cold induced pain test, and the central nervous system of healthy volunteers”. Br J Clin Pharmacol. 24 (1): 43—50. PMC 1386278  . PMID 3620284. doi:10.1111/j.1365-2125.1987.tb03134.x.

[5] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709  . PMID 21059682. doi:10.1093/nar/gkq1126.

[6] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889  . PMID 18048412. doi:10.1093/nar/gkm958.

[7] . doi:10.1021/jp980230o. Недостаје или је празан параметар |title= (помоћ)

[8] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[9] Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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