Triptofanska sintaza
Triptofanska sintaza (EC 4.2.1.20, L-triptofanska sintetaza, indolglicerol fosfatna aldolaza, triptofanska desmolaza, triptofanska sintetaza, L-serin hidrolijaza (dodaje indolglicerol-fosfat)) je enzim sa sistematskim imenom L-serin hidrolijaza (adding 1-C-(indol-3-il)glicerol 3-fosfat, L-triptofan and formira gliceraldehid-3-fosfat).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Triptofanska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.2.1.20 | ||||||||
| CAS broj | 9014-52-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-serin + 1-C-(indol-3-il)glicerol 3-fosfat L-triptofan + gliceraldehid 3-fosfat + H2O (sveukupna reakcija)
- (1a) 1-C-(indol-3-il)glicerol 3-fosfat indol + gliceraldehid 3-fosfat
- (1b) L-serin + indol L-triptofan +H2O
Ovaj enzim je piridoksal-fosfatni protein.
Reference
уреди- ^ Crawford, I.P. & Yanofsky, C. (1958). „On the separation of the tryptophan synthetase of Escherichia coli into two protein components”. Proc. Natl. Acad. Sci. USA. 44: 1161—1170. PMID 16590328.
- ^ Creighton, T.E. & Yanofsky, C. (1970). „Chorismate to tryptophan (Escherichia coli) - anthranilate synthetase, PR transferase, PRA isomerase, InGP synthetase, tryptophan synthetase”. Methods Enzymol. 17A: 365—380.
- ^ Hütter, R., Niederberger, P. and DeMoss, J.A. (1986). „Tryptophan synthetic genes in eukaryotic microorganisms”. Annu. Rev. Microbiol. 40: 55—77. PMID 3535653.
- ^ Hyde, C.C., Ahmed, S.A., Padlan, E.A., Miles, E.W. and Davies, D.R. (1988). „Three-dimensional structure of the tryptophan synthase α2β2 multienzyme complex from Salmonella typhimurium”. J. Biol. Chem. 263: 17857—17871. PMID 3053720.
- ^ Woehl, E. & Dunn, M.F. (1999). „Mechanisms of monovalent cation action in enzyme catalysis: the tryptophan synthase α-, β-, and αβ-reactions”. Biochemistry. 38: 7131—7141. PMID 10353823.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Tryptophan+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
