Xaa-Xaa-Pro tripeptidilna peptidaza
Xaa-Xaa-Pro tripeptidilna peptidaza (EC 3.4.14.12, proliltripeptidilna aminopeptidaza, proliltripeptidilna peptidaza, PTP-A, TPP) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Xaa-Xaa-Pro tripeptidilna peptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.14.12 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Hidroliza Xaa-Xaa-Pro--Yaa- uz odvajanje N-terminalnog tripeptida sa peptida koji ima Pro kao treći ostatak (pozicija P1) i gde Yaa nije prolin
Ova serin eksopeptidaza vezana za ćelijsku površinu je prisutna kod Gram-negativnih, anaerobnih bakterija Porphyromonas gingivalis.
Reference уреди
- ^ Banbula, A., Mak, P., Bugno, M., Silberring, J., Dubin, A., Nelson, D., Travis, J. and Potempa, J. (1999). „Prolyl tripeptidyl peptidase from Porphyromonas gingivalis. A novel enzyme with possible pathological implications for the development of periodontitis”. J. Biol. Chem. 274: 9246—9252. PMID 10092598.
- ^ Fujimura, S., Ueda, O., Shibata, Y. and Hirai, K. (2003). „Isolation and properties of a tripeptidyl peptidase from a periodontal pathogen Prevotella nigrescens”. FEMS Microbiol. Lett. 219: 305—309. PMID 12620636.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Xaa-Xaa-Pro+tripeptidyl-peptidase на US National Library of Medicine Medical Subject Headings (MeSH)
