Еритромицин 12 хидроксилаза
Eritromicin 12 hidroksilaza (EC 1.14.13.154, EryK) je enzim sa sistematskim imenom eritromicin-D,NADPH:kiseonik oksidoreduktaza (12-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Eritromicin 12 hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.154 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- eritromicin D + NADPH + H+ + O2 eritromicin C + NADP+ + H2O
Ovaj enzim je odgovoran za C-12 hidroksilaciju makrolaktonskog prstena, jedan od zadnjih koraka biosinteze eritromicina.
Reference
уреди- ^ Lambalot, R.H., Cane, D.E., Aparicio, J.J. and Katz, L. (1995). „Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK”. Biochemistry. 34: 1858—1866. PMID 7849045.
- ^ Savino, C., Montemiglio, L.C., Sciara, G., Miele, A.E., Kendrew, S.G., Jemth, P., Gianni, S. and Vallone, B. (2009). „Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate”. J. Biol. Chem. 284: 29170—29179. PMID 19625248.
- ^ Montemiglio, L.C., Gianni, S., Vallone, B. and Savino, C. (2010). „Azole drugs trap cytochrome P450 EryK in alternative conformational states”. Biochemistry. 49: 9199—9206. PMID 20845962.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Erythromycin+12+hydroxylase на US National Library of Medicine Medical Subject Headings (MeSH)
