Dutasterid
Dutasterid je organsko jedinjenje, koje sadrži 27 atoma ugljenika i ima molekulsku masu od 528,530 Da.[1][2][3][4]
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Klinički podaci | |
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Drugs.com | Monografija |
Način primene | Oralno |
Farmakokinetički podaci | |
Poluvreme eliminacije | 5 nedelja |
Izlučivanje | Fekalno |
Identifikatori | |
CAS broj | 164656-23-9 ![]() |
ATC kod | G04CB02 (WHO) |
PubChem | CID 6918296 |
DrugBank | DB01126 ![]() |
ChemSpider | 5293502 ![]() |
ChEBI | CHEBI:521033 ![]() |
ChEMBL | CHEMBL1200969 ![]() |
Hemijski podaci | |
Formula | C27H30F6N2O2 |
Molarna masa | 528,530 |
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Osobine
urediOsobina | Vrednost |
---|---|
Broj akceptora vodonika | 2 |
Broj donora vodonika | 2 |
Broj rotacionih veza | 4 |
Particioni koeficijent[5] (ALogP) | 5,7 |
Rastvorljivost[6] (logS, log(mol/L)) | -9,0 |
Polarna površina[7] (PSA, Å2) | 58,2 |
Reference
uredi- ^ Keam SJ, Scott LJ: Dutasteride: a review of its use in the management of prostate disorders. Drugs. 2008;68(4):463-85. PMID 18318566
- ^ Shah SK, Trump DL, Sartor O, Tan W, Wilding GE, Mohler JL: Phase II study of Dutasteride for recurrent prostate cancer during androgen deprivation therapy. J Urol. 2009 Feb;181(2):621-6. Epub 2008 Dec 16. PMID 19091347
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
uredi- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
uredi
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