Glikolipid 3-a-manoziltransferaza
Glikolipid 3-a-manoziltransferaza (EC 2.4.1.132, Alg2 manoziltransferaza, ALG2 (gen), glikolipid 3-alfa-manoziltransferaza, GDP-manoza:glikolipid 3-alfa-D-manoziltransferaza, GDP-Man:Man1GlcNAc2-PP-Dol alfa-1,3-manoziltransferaza) je enzim sa sistematskim imenom GDP-D-manoza:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol 3-alfa-manoziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glikolipid 3-a-manoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.132 | ||||||||
| CAS broj | 81181-76-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- GDP-D-manoza + D-MaN-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol GDP + D-MaN-alfa-(1->3)-D-MaN-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol
Pri biosintezi za asparagin vezanih glikoproteina (N-vezanoj proteinskoj glikozilaciji) se koristi za dolihil difosfat vezani glikozilni donor. Njega formira serija za membranu vezanih glikoziltransferaza.
Reference
uredi- ^ Kampf, M., Absmanner, B., Schwarz, M. and Lehle, L. (2009). „Biochemical characterization and membrane topology of Alg2 from Saccharomyces cerevisiae as a bifunctional α1,3- and 1,6-mannosyltransferase involved in lipid-linked oligosaccharide biosynthesis”. J. Biol. Chem. 284: 11900—11912. PMID 19282279.
- ^ O'Reilly, M.K., Zhang, G. and Imperiali, B. (2006). „In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis”. Biochemistry. 45: 9593—9603. PMID 16878994.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
uredi- GDP-Man:Man1GlcNAc2-PP-dolichol+alpha-1,3-mannosyltransferase na US National Library of Medicine Medical Subject Headings (MeSH)
