Glutationilspermidinska sintaza
Glutationilspermidinska sintaza (EC 6.3.1.8, glutation:spermidinska ligaza (formira ADP)) je enzim sa sistematskim imenom gama-L-glutamil-L-cisteinil-glicin:spermidin ligaza (formira ADP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glutationilspermidinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.1.8 | ||||||||
| CAS broj | 2621592 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Za dejstvo ovog enyima su neophodni joni magnezijuma.
Reference
uredi- ^ Smith, K., Nadeau, K., Bradley, M., Walsh, C.T., Fairlamb, A.H. (1992). „Purification of glutathionylspermidine and trypanothione synthase from Crithidia fasciculata”. Protein Sci. 1: 874—883. PMID 1304372.
- ^ Bollinger, J.M., Kwon, D.S., Huisman, G.W., Kolter, R., Walsh, C.T. (1995). „Glutathionylspermidine metabolism in E. coli. Purification, cloning, overproduction and characterization of a bifunctional glutathionylspermidine synthetase/amidase”. J. Biol. Chem. 270: 14031—14041. PMID 7775463.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
uredi- Glutathionylspermidine+synthase na US National Library of Medicine Medical Subject Headings (MeSH)
