Kjuin tRNK-riboziltransferaza
Kjuin tRNK-riboziltransferaza (EC 2.4.2.29, enzim umetanja kjuina, tRNK transglikozilaza, Q-insertaza, kjuin34 transfer ribonukleatna riboziltransferaza, transfer ribonukleatna glikoziltransferaza, tRNK kjuin34 transglikosidaza, kjuinska tRNK-riboziltransferaza, TGT, (tRNK)-kjuin34:kjuin tRNK-D-riboziltransferaza, transfer ribonukleinska kiselina kjuin34 transglikozilaza) je enzim sa sistematskim imenom tRNK-guanozin34:kjuin tRNK-D-riboziltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kjuin tRNK-riboziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.2.29 | ||||||||
| CAS broj | 72162-89-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) guanin34 u tRNK + kveuin kveuin34 u tRNK + guanin
- (2) guanin34 u tRNK + 7-aminometil-7-karbaguanin 7-aminometil-7-karbaguanin34 u tRNK + guanin
Pojedine prokariotske i eukariotske tRNK sadrže modifikovanu bazu kjuin u poziciji 34.
Reference
uredi- ^ Howes, N.K. & Farkas, W.R. (1978). „Studies with a homogeneous enzyme from rabbit erythrocytes catalyzing the insertion of guanine into tRNA”. J. Biol. Chem. 253: 9082—9087. PMID 721832.
- ^ Okada, N., Noguchi, S., Kasai, H., Shindo-Okada, N., Ohgi, T., Goto, T. and Nishimura, S. (1979). „Novel mechanism of post-transcriptional modification of tRNA. Insertion of bases of Q precursors into tRNA by a specific tRNA transglycosylase reaction”. J. Biol. Chem. 254: 3067—3073. PMID 372186.
- ^ Shindo-Okada, N., Okada, N., Ohgi, T., Goto, T. and Nishimura, S. (1980). „Transfer ribonucleic acid guanine transglycosylase isolated from rat liver”. Biochemistry. 19: 395—400. PMID 6986171.
- ^ Todorov, K.A. & Garcia, G.A. (2006). „Role of aspartate 143 in Escherichia coli tRNA-guanine transglycosylase: alteration of heterocyclic substrate specificity”. Biochemistry. 45: 617—625. PMID 16401090.
- ^ Boland, C., Hayes, P., Santa-Maria, I., Nishimura, S. and Kelly, V.P. (2009). „Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase”. J. Biol. Chem. 284: 18218—18227. PMID 19414587.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
uredi- TRNA-guanosine34+transglycosylase na US National Library of Medicine Medical Subject Headings (MeSH)
