Nitrilaza
Nitrilaza (EC 3.5.5.1, acetonitrilaza, benzonitrilaza) je enzim sa sistematskim imenom nitril aminohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Nitrilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.5.5.1 | ||||||||
| CAS broj | 9024-90-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- nitril + 2H2O karboksilat + NH3
Ovaj enzim deluje na širok opseg aromatičnih nitrila.
Reference
uredi- ^ Harper, D.B. (1977). „Microbial metabolism of aromatic nitriles. Enzymology of C-N cleavage by Nocardia sp. (rhodochrous group) N.C.I.B. 11216”. Biochem. J. 165: 309—319. PMID 21655.
- ^ Thimann, K.V. & Mahadevan, S. (1964). „Nitrilase. I. Occurrence, preparation, and general properties of the enzyme”. Arch. Biochem. Biophys. 105: 133—141. PMID 14165487.
- ^ Pace, H.C. & Brenner, C. (2001). „The nitrilase superfamily: classification, structure and function”. Genome Biol. 2: 0001.—001.9. PMID 11380987.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
