Trimetilamin dehidrogenaza
Trimetilamin dehidrogenaza (EC 1.5.8.2, trimetilaminska dehidrogenaza) je enzim sa sistematskim imenom trimetilamin:elektron-transfer flavoprotein oksidoreduktaza (demetilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Trimetilamin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.8.2 | ||||||||
| CAS broj | 39307-09-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- trimetilamin + H2O + elektron-transfer flavoprotein dimetilamin + formaldehid + redukovani elektron-transfer flavoprotein
Znata broj alkil-supstituisanih derivata trimetilamina takođe mogu da deluju kao elektronski donori.
Reference
uredi- ^ Colby, J. & Zatman, L.J. (1971). „The purification and properties of a bacterial trimethylamine dehydrogenase”. Biochem. J. 121: 9P—10P. PMID 5116569.
- ^ Steenkamp, D.J. & Singer, T.P. (1978). „Participation of the iron-sulphur cluster and of the covalently bound coenzyme of trimethylamine dehydrogenase in catalysis”. Biochem. J. 169: 361—369. PMID 204297.
- ^ Huang, L.X., Rohlfs, R.J. and Hille, R. (1995). „The reaction of trimethylamine dehydrogenase with electron transferring flavoprotein”. J. Biol. Chem. 270: 23958—23965. PMID 7592591.
- ^ Jones, M., Talfournier, F., Bobrov, A., Grossmann, J.G., Vekshin, N., Sutcliffe, M.J. and Scrutton, N.S. (2002). „Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein”. J. Biol. Chem. 277: 8457—8465. PMID 11756429.
- ^ Scrutton, N.S. & Sutcliffe, M.J. (2000). „Trimethylamine dehydrogenase and electron transferring flavoprotein”. Subcell. Biochem. 35: 145—181. PMID 11192721.
Literatura
uredi- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
uredi- Trimethylamine+dehydrogenase na US National Library of Medicine Medical Subject Headings (MeSH)
