Homocistein
Homocistein je neproteinska aminokiselina. On je homolog aminokiseline cisteina, od koje se razlikuje po dodatnoj metilenskoj (-CH2-) grupi. On se biosintetiše iz metionina uklanjanjem terminalne Cε metil grupe. Homocistein se može reciklisati u metionin ili konvertovati u cistein uz pomoć B-vitamina.
Nazivi | |
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IUPAC naziv
2-Amino-4-sulfanilbutanska kiselina
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Identifikacija | |
3D model (Jmol)
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ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.006.567 |
KEGG[1] | |
UNII | |
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Svojstva | |
C4H9NO2S | |
Molarna masa | 135,18 g/mol |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
verifikuj (šta je ?) | |
Reference infokutije | |
Detekcija visokih nivoa homocisteina je povezana sa kardiovaskularnim bolesima, mada snižavanje nivoa homocisteina ne poboljšava ishod oboljenja.[4] Povišeni novoi homocisteina su vezani za više stanja bolesti. Korisnost pokušaja snižavanja nivoa homocisteina je bilo nepotvrđena ili neubedljiva.[5][6][7][8]
Reference
уреди- ^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Martí-Carvajal AJ, Solà I, Lathyris D, Salanti G (2009). Martí-Carvajal, Arturo J, ур. „Homocysteine lowering interventions for preventing cardiovascular events”. Cochrane Database Syst Rev (4): CD006612. PMID 19821378. doi:10.1002/14651858.CD006612.pub2.
- ^ Martí-Carvajal, AJ; Solà, I; et al. (7. 10. 2009). „Homocysteine lowering interventions for preventing cardiovascular events.”. Cochrane database of systematic reviews (Online) (4): CD006612. PMID 19821378. doi:10.1002/14651858.CD006612.pub2.
- ^ Jardine, MJ; Kang, A; et al. (13. 6. 2012). „The effect of folic acid based homocysteine lowering on cardiovascular events in people with kidney disease: systematic review and meta-analysis.”. BMJ (Clinical research ed.). 344: e3533. PMC 3374481 . PMID 22695899.
- ^ Vizzardi, E; Bonadei, I; et al. (јануар 2009). „Homocysteine and heart failure: an overview.”. Recent patents on cardiovascular drug discovery. 4 (1): 15—21. PMID 19149701.
- ^ Ahmadieh, H; Arabi, A. (октобар 2011). „Vitamins and bone health: beyond calcium and vitamin D.”. Nutrition Reviews. 69 (10): 584—98. PMID 21967159. doi:10.1111/j.1753-4887.2011.00372.x.
Spoljašnje veze
уреди- David Spence on homocysteine levels, kidney damage, and cardiovascular disease, The Health Report, Radio National, 24 May 2010