IRNK (nukleozid-2'-O-)-metiltransferaza
iRNK (nukleozid-2'-O-)-metiltransferaza (EC 2.1.1.57, informacioni ribonukleatni nukleozid 2'-metiltransferaza, informacioni RNK (nukleozid-2'-)-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:iRNK (nukleozid-2'-O)-metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| iRNK (nukleozid-2'-O-)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.57 | ||||||||
| CAS broj | 61970-02-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + m7G5'ppp5'R-iRNK S-adenozil-L-homocistein + m7G5'ppp5'Rm-iRNK
Nukleozid pored terminalnog guanozina može da bude bilo guanozin ili adenozin. Formiranje 2'-O-metiladenozinske kape je ranije bilo klasifikovano kao EC 2.1.1.58.
Reference
уреди- ^ Barbosa, E. & Moss, B. (1978). „mRNA(nucleoside-2′-)-methyltransferase from vaccinia virus. Purification and physical properties”. J. Biol. Chem. 253: 7692—7697. PMID 701281.
- ^ Barbosa, E. & Moss, B. (1978). „mRNA(nucleoside-2′-)-methyltransferase from vaccinia virus. Characteristics and substrate specificity”. J. Biol. Chem. 253: 7698—7702. PMID 701282.
- ^ Boone, R.F., Ensinger, M.J. and Moss, B. (1977). „Synthesis of mRNA guanylyltransferase and mRNA methyltransferases in cells infected with vaccinia virus”. J. Virol. 21: 475—483. PMID 833934.
- ^ Ensinger, M.J., Martin, S.A., Paoletti, E. and Moss, B. (1975). „Modification of the 5′-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus”. Proc. Natl. Acad. Sci. USA. 72: 2525—2529. PMID 1058472.
- ^ Groner, Y., Gilbao, E. and Aviv, H. (1978). „Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates”. Biochemistry. 17: 977—982. PMID 629955.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- MRNA+(nucleoside-2'-O)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
