Aciklovir je organsko jedinjenje, koje sadrži 8 atoma ugljenika i ima molekulsku masu od 225,205 Da.[1][2][3][4]

Aciklovir
Klinički podaci
Prodajno imeAlti-Acyclovir, Avirax, Sitavig, Vipral
Drugs.comMonografija
Način primeneOralno, topikalno, intravenozno
Farmakokinetički podaci
Poluvreme eliminacije2,5-3,3 h
IzlučivanjeRenalno
Identifikatori
CAS broj59277-89-3 ДаY
ATC kodD06BB03 (WHO), J05AB11
PubChemCID 2022
DrugBankDB00787 ДаY
ChemSpider1945 ДаY
KEGGC06810 ДаY
ChEBICHEBI:2453 ДаY
ChEMBLCHEMBL184 ДаY
Hemijski podaci
FormulaC8H11N5O3
Molarna masa225,205
  • NC1=NC(=O)C2=C(N1)N(COCCO)C=N2
  • InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15) ДаY
  • Key:MKUXAQIIEYXACX-UHFFFAOYSA-N ДаY
Fizički podaci
Tačka topljenja255 °C (491 °F)
Osobina Vrednost
Broj akceptora vodonika 7
Broj donora vodonika 3
Broj rotacionih veza 4
Particioni koeficijent[5] (ALogP) -1,4
Rastvorljivost[6] (logS, log(mol/L)) -0,5
Polarna površina[7] (PSA, Å2) 114,8

Reference

уреди
  1. ^ O'Brien JJ, Campoli-Richards DM: Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1989 Mar;37(3):233-309. PMID 2653790
  2. ^ Gunness P, Aleksa K, Bend J, Koren G: Acyclovir-induced nephrotoxicity: the role of the acyclovir aldehyde metabolite. Transl Res. 2011 Nov;158(5):290-301. doi: 10.1016/j.trsl.2011.07.002. Epub 2011 Aug 3. PMID 22005269
  3. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. 
  4. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. 
  5. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  6. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  7. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

уреди

Spoljašnje veze

уреди


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