Cilazapril

Cilazapril
Nazivi
	IUPAC naziv (1S,9S)-9-[(2S)-(1-Etoksi-1-okso-4-fenilbutan-2-il)amino]-10-okso-oktahidro-1H-piridazino[1,2-a][1,2]diazepin-1-karboksilna kiselina
Identifikacija
CAS broj	88768-40-5 ;
3D model (Jmol)	interaktivna slika;
ChemSpider	50831 ;
DrugBank	DB01340 ;
ECHA InfoCard	100.168.764
KEGG	D07699 ;
PubChem C ID	56330; 40467985 (1R,9S)-(2S)-butilamino izomer;
UNII	8Q9454114Q ;
	SMILES CCOC(=O)C(CCc1ccccc1)NC1CCCN2CCCC(N2C1=O)C(O)=O; ; ; ; ; ;
Svojstva
Hemijska formula	C22H31N3O5
Molarna masa	417,51 g·mol−1
log P	2,212
Kiselost (pKa)	2,285
Baznost (pKb)	11,712
Farmakologija
Načini upotrebe	Oralno
Legalni status	UK: POM (Само на рецепат) ;
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Cilazapril je inhibitor angiotenzin konvertujućeg enzima (ACE inhibitor) koji se koristi za tretiranje hipertenzije i zatajenja srca.^[4]^[5] Neka od prodajnih imena ovog leka su: Inhibace, Vascace i Dynorm.^[6]^[7]

Osobine уреди

Osobina	Vrednost
Broj akceptora vodonika	7
Broj donora vodonika	2
Broj rotacionih veza	9
Particioni koeficijent^[8] (ALogP)	-0,7
Rastvorljivost^[9] (logS, log(mol/L))	-3,5
Polarna površina^[10] (PSA, Å²)	99,2

Reference уреди

^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Szucs, T. (1991). „Cilazapril. A review”. Drugs. 41 Suppl 1: 18—24. PMID 1712267.
^ Jasek, W, ур. (2007). Austria-Codex (на језику: German) (2007/2008 изд.). Vienna: Österreichischer Apothekerverlag. ISBN 978-3-85200-181-4.
^ Drugs.com: Cilazapril
^ Cilazapril monograph. Lexi-Comp Online, Lexi-Drugs Online, Lexi-Comp Inc. Hudson, OH. Available at: [1] Архивирано на сајту Wayback Machine (16. новембар 2004). Accessed October 5, 2008.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. уреди
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. уреди

Literatura уреди

Clayden, Jonathan; Greeves, Nick; Warren, Stuart; Wothers, Peter (2001). Organic Chemistry (I изд.). Oxford University Press. ISBN 978-0-19-850346-0.
Smith, Michael B.; March, Jerry (2007). Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (6th изд.). New York: Wiley-Interscience. ISBN 0-471-72091-7.
Katritzky A.R.; Pozharskii A.F. (2000). Handbook of Heterocyclic Chemistry (Second изд.). Academic Press. ISBN 0080429882.

Spoljašnje veze уреди

Cilazapril

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[3] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[4] Szucs, T. (1991). „Cilazapril. A review”. Drugs. 41 Suppl 1: 18—24. PMID 1712267.

[5] Jasek, W, ур. (2007). Austria-Codex (на језику: German) (2007/2008 изд.). Vienna: Österreichischer Apothekerverlag. ISBN 978-3-85200-181-4.

[6] Drugs.com: Cilazapril

[7] Cilazapril monograph. Lexi-Comp Online, Lexi-Drugs Online, Lexi-Comp Inc. Hudson, OH. Available at: [1] Архивирано на сајту Wayback Machine (16. новембар 2004). Accessed October 5, 2008.

[8] Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.

[9] Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. уреди

[10] Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. уреди

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