Fluoroacetaldehid dehidrogenaza
Fluoroacetaldehid dehidrogenaza (EC 1.2.1.69, fluoroacetaldehidna dehidrogenaza) je enzim sa sistematskim imenom fluoroacetaldehid:NAD+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fluoroacetaldehid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.69 | ||||||||
| CAS broj | 387336-50-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- fluoroacetaldehid + NAD+ +H2O fluoroacetat + NADH + 2 H+
Ovaj enzim iz Streptomyces cattleya ima visok afinitet za fluoroacetat i glikolaldehid, ali ne za acetaldehid.
Reference
уреди- ^ Murphy, C.D., Moss, S.J. and O'Hagan, D. (2001). „Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya”. Appl. Environ. Microbiol. 67: 4919—4921. PMID 11571203.
- ^ Murphy, C.D., Schaffrath, C. and O'Hagan, D. (2003). „Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya”. Chemosphere. 52: 455—461. PMID 12738270.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Fluoroacetaldehyde+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
